Selective Serotonin Reuptake Inhibitors and Myocardial Infarction

Selective Serotonin Reuptake Inhibitors and Myocardial Infarction

Background—Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. Methods and Results—A case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-coun...

Selective serotonin reuptake inhibitors and myocardial infarction.

BACKGROUND Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. METHODS AND RESULTS case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-coun...

Use of selective serotonin reuptake inhibitors and myocardial infarction.

Myocardial Infarction To the Editor: In a recent study, Sauer et al1 showed that the use of selective serotonin reuptake inhibitor antidepressants (SSRIs) may confer a protective effect against myocardial infarction (MI) in smokers. They hypothesized that this beneficial effect of SSRIs in reducing the risk of MI could mainly be attributed to the inhibitory effect on serotonin-mediated platelet...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.